Facile and efficient syntheses of carboxylic anhydrides and amides using (trimethylsilyl) ethoxyacetylene

…, S Akai, N Ajimura, M Yoshigi, T Tsugoshi…

Index: Kita, Yasuyuki; Akai, Shuji; Ajimura, Naomi; Yoshigi, Mayumi; Tsugoshi, Teruhisa; et al. Journal of Organic Chemistry, 1986 ,  vol. 51,  # 22  p. 4150 - 4158

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Citation Number: 103

Abstract

(Trimethylsilyl) ethoxyacetylene, a stable and easy-handling reagent, serves as an excellent dehydrating agent for the synthesis of carboxylic anhydrides and amides from the corresponding carboxylic acids. By means of this reagent, various types of acid-sensitive carboxylic anhydrides and amides were obtained almost in quantitative yields. Twenty-two examples of carboxylic anhydrides and 12 examples of amides were presented.