The synthesis and activity of spiroindane growth hormone secretagogues

…, B Butler, TM Jacks, G Hickey, R Smith

Index: Tata, James R.; Nargund, Ravi P.; Murphy, Marcia M.; Johnston, David B. R.; Patchett, Arthur A.; Cheng, Kang; Wei, Liente; Chan, Wanda W.-S.; Butler, Bridget; Jacks, Thomas M.; Hickey, Gerard; Smith, Roy Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 663 - 668

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Citation Number: 25

Abstract

The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported.