INTRODUCTION Ibutilide fumarate (1, raceme, Fig. 1) is a class III intravenous antiarrhythmic agent indicated for the acute termination of atrial fibrillation and flutter. Ibutilide prolongs repolarization in the atria and ventricle by enhancing the inward depolarizing, slow sodium current, a unique mechanism of action for a classic III agent. After intravenous administration, Ibutilide is moderately effective in achieving prompt cardioversion to sinus rhythm, with greater efficacy in ...
