Process development for the synthesis of 5′-O-(4, 4′-dimethoxytrityl)-N 2-isobutyryl-2′-O-(2-methoxyethyl)-guanosine—a potential precursor for the second …

…, P Gurumurthy, R Suresh, S Narayanan…

Index: Taj, Shabbir Ali S.; Gurumurthy; Suresh; Narayanan; Meenakshi, S. Suman; Sanghvi, Yogesh S. Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 5-8 p. 1327 - 1330

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Citation Number: 6

Abstract

Abstract An efficient four step process for the preparation of 5′-O-(4, 4′-dimethoxytrityl)-N 2-isobutyryl-2′-O-(2-methoxyethyl)-guanosine 1 was developed. Direct 2′-O-alkylation of 2, 6-diaminopurine riboside 2 was accomplished via inexpensive and commercially available reagents such as KOH, DMSO and alkyl halides at room temperature in 4–6 hrs. Pure 2′-O-(2-methoxyethyl)-DAPR 3 was isolated by crystallization from methanol. ...