GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted β-amino acid derivatives, and a substituted benzamidine structure

Y Hayashi, J Katada, T Harada, A Tachiki…

Index: Hayashi, Yoshio; Katada, Jun; Harada, Takeo; Tachiki, Akira; Iijima, Kiyoko; Takiguchi, Yoshimi; Muramatsu, Michiko; Miyazaki, Hiroshi; Asari, Tohru; Okazaki, Takeo; Sato, Yoshimi; Yasuda, Emiko; Yano, Mako; Uno, Isao; Ojima, Iwao Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2345 - 2360

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Citation Number: 46

Abstract

Ethyl N-[3-(2-fluoro-4-(thiazolidin-3-yl (imino) methyl) benzoyl) amino-2, 2- dimethylpentanoyl] piperidine-4-acetate 40 (NSL-96184) is a highly potent and orally active fibrinogen receptor antagonist, which is characterized by the presence of the trisubstituted β- amino acid residue, 3-ethyl-2, 2-dimethyl-β-alanine. This compound was developed on the basis of the SAR study of N-[3-(N-4-amidinobenzoyl) amino-2, 2-dimethyl-3- ...