Anticancer activity of phenolic acids of natural or synthetic origin: a structure-activity study

…, T Girão da Cruz, JL Andrade, N Milhazes…

Index: Gomes, Catarina A.; Girao Da Cruz, Teresa; Andrade, Jose L.; Milhazes, Nuno; Borges, Fernanda; Marques, M. Paula M. Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5395 - 5401

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Citation Number: 166

Abstract

Several phenolic acids caffeic and gallic acid derivatives were synthesized and screened for their potential antiproliferative and cytotoxic properties, in different human cancer cell lines: mammary gland and cervix adenocarcinomas and lymphoblastic leukemia. The selected phenols were structurally related, which allowed us to gather important information regarding the structure-activity relationships underlying the biological activity of such ...