Preparation of labelled 2??methoxy??3??alkylpyrazines: synthesis and characterization of deuterated 2??methoxy??3??isopropylyrazine and 2??methoxy??3??isobutylpyrazine

DA Gerritsma, ID Brindle, TRB Jones…

Index: Gerritsma, David A.; Brindle, Ian D.; Jones, Timothy R.B.; Capretta, Alfredo Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 3 p. 243 - 253

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Citation Number: 9

Abstract

Abstract Efficient synthetic routes for a number of deuterated analogues of 2-methoxy-3- isopropylpyrazines and 2-methoxy-3-isobutylpyrazines have been developed involving the condensation of glyoxal with an α-amino acid amide followed by methylation with iodomethane. In this way [2 H 3] 2-methoxy-3-isopropylpyrazine, 2-methoxy-3-isopropyl-[2 H 2] pyrazine,[2 H 3] 2-methoxy-3-isopropyl-[2 H 2] pyrazine,[2 H 3] 2-methoxy-3- ...