This work presents a facile approach for preparation of acid-labile and biocompatible polymers with pendent cyclic ortho esters, which is based on the efficient and mild reactions between cyclic ketene acetal (CKA) and hydroxyl groups. Three CKAs, 2-ethylidene-1, 3- dioxane (EDO), 2-ethylidene-1, 3-dioxolane (EDL), and 2-ethylidene-4-methyl-1, 3- dioxolane (EMD) were prepared from the corresponding cyclic vinyl acetals by catalytic ...
