Abstract A general concept for the stabilization of β-sheetsby designed artificial ligands is introduced. The ligands have twokey features: they contain acylated 3-aminopyrazoles with a DAD hydrogenbond donor and acceptor pattern, and they were synthesized as oligomersin order to multiply their hydrogen bond interactions with peptidesin the β-sheet conformation. Dimeric aminopyrazoles wereaccessible by reaction of the N1-Boc- ...
![2-[(4-methoxyphenyl)methyl]-5-nitropyrazole-3-carboxylic acid Structure](https://image.chemsrc.com/caspic/376/625386-11-0.png)
