Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents

…, KL Stone, KD Miller, GW Sledge, GD Hutchins

Index: Fei, Xiangshu; Zheng, Qi-Huang; Liu, Xuan; Wang, Ji-Quan; Sun, Hui Bin; Mock, Bruce H.; Stone, K. Lee; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 13 p. 2217 - 2222

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Citation Number: 32

Abstract

Novel matrix metalloproteinase (MMP) inhibitor radiotracers,(S)-3-methyl-2-(2′, 3′, 4′- methoxybiphenyl-4-sulfonylamino)-butyric acid [11C] methyl ester (1a–c),(S)-3-methyl-2- (2′, 3′, 4′-fluorobiphenyl-4-sulfonylamino)-butyric acid [11C] methyl ester (1d–f), and (S)- 3-methyl-2-(4′-nitrobiphenyl-4-sulfonylamino)-butyric acid [11C] methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as ...