Synthesis and biological evaluation of some new pyrazoline substituted benzenesulfonylurea/thiourea derivatives as anti-hyperglycaemic agents and aldose …

…, GB Reddy, P Rathore, R Bashir, S Yaseen…

Index: Ovais, Syed; Bashir, Rafia; Yaseen, Shafiya; Rathore, Pooja; Samim, Mohammed; Javed, Kalim Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1378 - 1385

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Citation Number: 9

Abstract

Abstract Seventeen new pyrazoline substituted benzenesulfonylurea/thiourea derivatives (2a–q) were synthesized and characterized by elemental analysis and various spectroscopic techniques viz; IR, 1 H NMR, 13 C NMR, and MS data. Thirteen compounds showed moderate to good anti-hyperglycaemic activity in glucose fed hyperglycaemic normal rats at the dose of 0.05 mM/kg bw On the basis of docking results nine compounds ...