Chemoenzymatic Approach toward the Pure Enantiomers of 2??Methyl??1, 3??propanediol Mono (p??Methoxybenzyl Ether)

T Akeboshi, Y Ohtsuka, T Ishihara…

Index: Akeboshi, Tomohiro; Ohtsuka, Yoshikazu; Ishihara, Takashi; Sugai, Takeshi Advanced Synthesis and Catalysis, 2001 , vol. 343, # 6-7 p. 624 - 637

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Citation Number: 18

Abstract

Abstract In a route towards the enantiomerically pure 2-methylpropane-1, 3-diol mono (p- methoxybenzyl ether), which is an important starting material for natural product synthesis, a kinetic resolution approach by means of lipase-catalyzed hydrolysis as well as acylation has been elaborated. Candida antarctica lipase-catalyzed hydrolysis of the corresponding racemic acetate proceeded with high enantioselectivity (E 35). During the studies, a ...