Novel N-indolylmethyl substituted spiroindoline-3, 2′-quinazolines were designed as potential inhibitiors of SIRT1. These compounds were synthesized in good yields by using Pd/C–Cu mediated coupling-cyclization strategy as a key step involving the reaction of 1- (prop-2-ynyl)-1′ H-spiro [indoline-3, 2′-quinazoline]-2, 4′(3′ H)-dione with 2- iodoanilides. Some of the compounds synthesized have shown encouraging inhibition of ...
