The Journal of Organic Chemistry

Absolute configuration of glycerol derivatives. 8. 2-Hydroxy-3-(1-naphthoxy) propionic acid, a major oxidative metabolite of the. beta.-adrenergic antagonist …

WL Nelson, MJ Bartels

Index: Nelson, Wendel L.; Bartels, Michael J Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1574 - 1576

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Citation Number: 7

Abstract

Propranolol (1) is a &adrenergic antagonist used extensively in the treatment of various cardiovascular disorders, including hypertension and angina pectoris, as well as in other situations. 2 In man, 2-hydroxy-3-(l-naphth-0xy) propionic acid (2;“propranolol lactic acid”) is the major urinary metabolite resulting from multistep oxidative N-dealkylation of the propanolamine side chain. 3 Because the P-adrenergic antagonist properties of the ...