Tetrahedron letters

Facile synthesis of 2H-indazole derivatives starting from the Baylis–Hillman adducts of 2-cyclohexen-1-one

KY Lee, S Gowrisankar, JN Kim

Index: Lee, Ka Young; Gowrisankar, Saravanan; Kim, Jae Nyoung Tetrahedron Letters, 2005 , vol. 46, # 32 p. 5387 - 5391

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Citation Number: 76

Abstract

The indazole nucleus is a pharmaceutically important structure and constitutes the key subunit in many drug substances with a broad range of pharmacological activities 1 including antitumor, 1b antimicrobial, 1h and antiplatelet, 1d and anti-inflammatory activities. 1j However, there is still a lack of general and efficient methodologies for the synthesis of N-substituted indazoles 2 although some of the reported methods could be used effectively.