Enantioselective Preparation of δ??Valerolactones with Horse Liver Alcohol Dehydrogenase

A Díaz??Rodríguez, J Iglesias??Fernández…

Index: Diaz-Rodriguez, Alba; Iglesias-Fernandez, Javier; Rovira, Carme; Gotor-Fernandez, Vicente ChemCatChem, 2014 , vol. 6, # 4 p. 977 - 980

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Citation Number: 2

Abstract

Abstract Horse liver alcohol dehydrogenase (HLADH) has been found to be a versatile biocatalyst for the desymmetrization of prochiral 3-arylpentane-1, 5-diols, based on a two- step one-pot oxidation. This procedure has allowed the formation of valuable (S)-lactones in good to excellent conversions and enantiomeric excess. The catalytic performance of HLADH has been studied using several cofactor regeneration systems and cosolvents, ...