Synthesis of phthalimido or succinimido-[2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl) ethyl} amino]-1, 3-thiazolidin-5-yl] ethanoate and their antimicrobial …

…, S Sharma, C Sharma, D Bhambi, GL Talesara

Index: Salvi, Vijay Kumar; Sharma, Shweta; Sharma, Chirag; Bhambi, Dinesh; Talesara Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 11 p. 1583 - 1589

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Citation Number: 8

Abstract

Keeping in view the pharmacological potential of thiazolidinones and phenothiazines, the title compounds containing these nuclei have been synthesized. Reaction of 10- (chloroacetyl) phenothiazine 1 with hydrazine hydrate gives 10-(hydrazinoacetyl) phenothiazine 2, which on treatment with various aromatic aldehydes yields 10-[4- (arylidene) hydrazino acetyl] phenothiazine 3a-d. These Schiff bases 3a-d underwent ...