Aza-amino acid scan for rapid identification of secondary structure based on the application of N-Boc-Aza1-dipeptides in peptide synthesis

RE Melendez, WD Lubell

Index: Melendez, Rosa E.; Lubell, William D. Journal of the American Chemical Society, 2004 , vol. 126, # 21 p. 6759 - 6764

Full Text: HTML

Citation Number: 75

Abstract

Azapeptides, peptide analogues in which the α-carbon of one or more of the amino acid residues is replaced with a nitrogen atom, exhibit propensity for adopting β-turn conformations. A general protocol for the synthesis of azapeptides without racemization on solid phase has now been developed by introducing the aza-amino acid residue as an N- Boc-aza1-dipeptide. This approach has been validated by the synthesis of six N-Boc-aza1 ...