Pleuromutilins. Part 1: the identification of novel mutilin 14-carbamates

G Brooks, W Burgess, D Colthurst, JD Hinks…

Index: Brooks, Gerald; Burgess, Wendy; Colthurst, David; Hinks, Jeremy D.; Hunt, Eric; Pearson, Michael J.; Shea, Burdena; Takle, Andrew K.; Wilson, Jennifer M.; Woodnutt, Gary Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1221 - 1231

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Citation Number: 69

Abstract

A novel series of mutilin 14-carbamates has been discovered as a result of structure–activity studies on the naturally occurring antibiotic pleuromutilin (1). In particular, the 4- methoxybenzoylcarbamate, SB-222734 (15o) displays potent antibacterial activity against a number of bacterial pathogens which are resistant to currently used agents and shows enhanced metabolic stability when compared to earlier pleuromutilin derivatives. Such ...