Journal of medicinal chemistry

Estrogen potentiating activity of two spiro compounds having approximately similar molecular dimensions to stilbestrol

NS Doggett, DJ Bailey, T Qazi

Index: Doggett,N.S. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 318 - 320

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Citation Number: 3

Abstract

Pharmacological investigation of members of a series of synthetic spiro derivatives with similar molecular dimensions to stilbestrol revealed that two compounds, spiro [cyclohexane- l, 2'-tetralin]-1, 4'-dione and spiro [cyclohexane-1, 2'-indan]-1, 4'-diol, exhibited a marked ability to potentiate stilbestrol at doses which had no intrinsic estrogenic activity. It is postulated that such compounds may be of use in reducing the side effects associated ...