Tetrahedron

Solid phase synthesis of guanidines

S Robinson, EJ Roskamp

Index: Robinson, Shaughnessy; Roskamp, Eric J. Tetrahedron, 1997 , vol. 53, # 19 p. 6697 - 6705

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Citation Number: 68

Abstract

A comparison of guanylating agents 1 and 2 was performed on a series of primary, secondary and aromatic amines in solution and on solid phase resins. Thiourea 1 performed well in solution and on solid supported primary and secondary amines. Pyrazole 2 performed well in each case, except one aniline which failed to react.