One-step synthesis of chromene-3-carboxamide, bis-chromene, chromeno [3, 4-c] pyridine and bischromeno [3, 4-c] pyridine derivatives for antimicrobial evaluation

MH Helal, EH Ali, AM Gameel, AA Ali…

Index: Helal, Mohamed H.; El-Hag Ali, Gameel A. M.; Ali, Ahmed A.; Ammar, Yousry A. Journal of Chemical Research, 2010 , # 8 p. 465 - 469

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Citation Number: 5

Abstract

Cyanoacetamide derivatives were reacted with salicylaldehyde under different conditions afforded chromenes and coumarin derivatives respectively. A number of chromeno [3, 4-c] pyridine derivatives were prepared from the reaction of N-cyclohexyl-2-imino-2H-chromene- 3-carboxamide with malononitrile and/or cynaothiocatemaide. Bischromeno [3, 4-c] pyridine derivatives were prepared from the reaction of N, N'-(ethane-1, 2-diyl) bis (2-imino-2H- ...