Organocatalytic Asymmetric Synthesis of β??Aryl?螃漫?isocyano Esters

F Morana, A Basso, M Bella, R Riva…

Index: Morana, Fabio; Basso, Andrea; Bella, Marco; Riva, Renata; Banfi, Luca Advanced Synthesis and Catalysis, 2012 , vol. 354, # 11-12 p. 2199 - 2210

Full Text: HTML

Citation Number: 7

Abstract

Abstract The asymmetric addition of malonates to in situ generated N-formylimines of aromatic aldehydes was achieved under phase-transfer catalysis using Cinchona alkaloids- derived quaternary ammonium salts. The resulting β-formamidomalonates have been efficiently converted into β-aryl-β-isocyano esters. Their utility in the multicomponent Ugi reaction with chiral cyclic imines has been demonstrated.