Synthesis and biological activity of mercaptothiocarboxylic acids and their cyclic analogs

…, TP Vasil'eva, VM Bystrova, OV Kil'disheva…

Index: Lisina, N. I.; Vasil'eva, T. P.; Bystrova, V. M.; Kil'disheva, O. V.; Chernov, G. A. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 2 p. 104 - 109 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 2 p. 177 - 181

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Citation Number: 4

Abstract

This method, however, is limited because of the poor availability and instability of the starting materials, We developed an original means of synthesis of not only the a-acylamino compound I, but also the previously unknown 8-mercaptothiolalkanoic acids (III, IV), by the reaction of~-propiothiolactone with HaS in the presence of triethylamlne. The compounds I were obtained in high yield (78%) by this method (Table I). 8-Mercaptothiolpropionic acid ...