The reaction of 3, 5-dimethylisoxazole with carbonyl compounds.

C Kashima, M Uemori, Y Tsuda, Y Omote

Index: Kashima,C. et al. Bulletin of the Chemical Society of Japan, 1976 , vol. 49, p. 2254 - 2258

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Citation Number: 13

Abstract

The reaction product of 3, 5-dimethylisoxazole (1) with methyl benzoate was found to be 3- methyl-5-(benzoylmethyl) isoxazole in the presence of sodium amide in liquid ammonia. On the other hand, the reaction of 1 with ethyl acetate did not give 3-methyl-5-acetonylisoxazole under similar conditions. The latter reaction product was, however, obtained in a good yield in the presence of lithium amide in liquid ammonia. The reaction of 1 with ketones and ...