Benzocycloheptenes and heterocyclic analogues as potential drugs. III. Further synthetic experiments in the series of 1-benzothiepin derivatives

K Šindelář, E Svátek, B Kakáč, F Hradil…

Index: Sindelar,K. et al. Collection of Czechoslovak Chemical Communications, 1972 , vol. 37, p. 1195 - 1206

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Citation Number: 4

Abstract

Attempts at C-alkylation of 2, 3-dihydro-4H-l-benzothiepin-5-one (1) reached their goal only if the starting compound was activated by a form of 4-ethoxycarbonyl derivative (II) or pyrrolidine enamine (V); compounds III and IV were obtained in low yields. Using 8 steps, compound XVI was synthesized from ketone I. C-Alkylation of 5-phenyl-2, 3, 4, 5-tetrahydro-l- benzothiepin (XVIII) led to a low yield of 5-(3-dimethylaminopropyl) derivative XIX. ...