The alkylation of malonic and acetoacetic esters is widely used for the synthesis of polyfunctional compounds.1(a)–(c) Classical alkylation procedures,1(a)–(c) alkylations in dipolar aprotic sol- vents2(a),(b) and under phase-transfer catalysis conditions3(a)–(f) are often complicated by using flammable organic solvents and difficulties in their regeneration, as well as in the regeneration of phase-transfer catalysts and in the isolation of reaction products. These problems can ...
