In a recent publication the synthesis of 4-(@-hydroxyphenyl)-hexahydropropiophenone, 11, was described. l This compound was suggested as an “open-model” of estrone, I. An investigation in this Laboratory directed toward the same objective has resulted in the preparation of l-methyl-3-ethyl-4-(p-hydroxyphenyl)-A3-cyclohexenylethylcarbinol, 111, which may be considered as an “open model” of estradiol. For. the preparation of I11 the ...
