Traceless approach for the synthesis of 3, 5-disubstituted thiohydantoins on functionalized ionic-liquid support

C Yao, Y Zhang, G Zhang, W Chen, Y Yu…

Index: Yao, Chao; Zhang, Yandong; Zhang, Guolin; Chen, Wenteng; Yu, Yongping; Houghten, Richard A. Synthetic Communications, 2010 , vol. 40, # 5 p. 717 - 724

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Citation Number: 6

Abstract

A traceless approach for the synthesis of 3, 5-disubstituted thiohydantoins on a novel functionalized ionic-liquid support, 5, is described. Acylation of benzylamine functionalized ionic-liquid support with amino acids yielded ionic-liquid-supported amino acids, which reacted with isothiocyanates to afford ionic-liquid-supported thioureas. Following intramolecular cyclization cleavage from the ionic-liquid support by trifluoroacetic acid ( ...