Synthesis of N 4-Alkyl-5-azacytidines and Their Base-Pairing with Carbamoylguanidines-A Contribution to Explanation of the Mutagenicity of 2'-Deoxy-5-azacytidine

…, M Masojídková, M Otmar, P Fiedler…

Index: Piskala, Alois; Hanna, Naeem B.; Masojidkova, Milena; Otmar, Miroslav; Fiedler, Pavel; Ubik, Karel Collection of Czechoslovak Chemical Communications, 2003 , vol. 68, # 4 p. 711 - 743

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Citation Number: 8

Abstract

Abstract A series of N 4-alkyl-5-azacytidines 3a-3h were prepared by treatment of the 4- methoxy analogue 4 with the respective amines. In the case of propyl-, butyl-, sec-butyl-, benzyl-or furfurylamine, aggregates of azacytidines 3a-3e with their hydrolytic products 5a- 5e were isolated. Similar aggregates were obtained with 1-methyl-5-azacytosine (6) and 2- (methylcarbamoyl) guanidine (7). Compound 7 was prepared by the reaction of guanidine ...