Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-Resistant viral …

…, WA Schleif, L Gabryelski, DB Olsen, M Stahlhut…

Index: Cheng, Yuan; Zhang, Fengqi; Rano, Thomas A; Lu, Zhijian; Schleif, William A; Gabryelski, Lori; Olsen, David B; Stahlhut, Mark; Rutkowski, Carrie A; Lin, Jiunn H; Jin, Lixia; Emini, Emilio A; Chapman, Kevin T; Tata, James R Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 17 p. 2419 - 2422

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Citation Number: 21

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Indinavir analogues with blocked metabolism sites show highly improved pharmacokinetic profiles in animals. The cis-aminochromanol substituted analogues exhibited excellent potency against both the wild-type (NL4-3) virus and protease inhibitor-resistant HIV strains.

A new synthesis of CIS-3-substituted CHROMAN-4-Ols

[Venkati; Krupadanam, G. L. David Synthetic Communications, 2002 , vol. 32, # 14 p. 2227 - 2235]

Design and synthesis of HIV-1 protease inhibitors for a long...

[Kesteleyn, Bart; Amssoms, Katie; Schepens, Wim; Hache, Geerwin; Verschueren, Wim; Van De Vreken, Wim; Rombauts, Klara; Meurs, Greet; Sterkens, Patrick; Stoops, Bart; Baert, Lieven; Austin, Nigel; Wegner, Joerg; Masungi, Chantal; Dierynck, Inge; Lundgren, Stina; Joensson, Daniel; Parkes, Kevin; Kalayanov, Genadiy; Wallberg, Hans; Rosenquist, Asa; Samuelsson, Bertil; Van Emelen, Kristof; Thuring, Jan Willem Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 310 - 317]