Letters in Organic Chemistry

Practical Corey-Chaykovsky Epoxidation: Scope and Limitation

H Yu, X Deng, S Cao, J Xu

Index: Yu, Hao; Deng, Xiaobing; Cao, Shengli; Xu, Jiaxi Letters in Organic Chemistry, 2011 , vol. 8, # 7 p. 509 - 514

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Abstract

Corey-Chaykovsky epoxidation is one of the versatile methods for synthesis of structurally diverse oxiranes. The extension of simplified Corey-Chaykovsky epoxidation has been investigated. Ketones and aromatic aldehydes were epoxidized in satisfactory to excellent yields with trimethylsulfonium iodide as an ylide precursor and crushed potassium hydroxide as a base in tertiary butanol. The scope and limitation of the simplified procedure were ...