2-Fluoroformycin and 2-aminoformycin. Synthesis and biological activity

…, AT Shortnacy, JA Montgomery

Index: Secrist, John A.; Shortnacy, Anita T.; Montgomery, John A. Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1740 - 1742

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Citation Number: 22

Abstract

Ba~ aadenosine,~ and 8-amino-6-fluoro-9-(/3-D-ribof~ ranosy1) purine.~ A nucleoside antibiotic that has attracted considerable interest is formycin A (% a), a C-nucleoside closely resembling adenosine (N-9 and C-8 of adenosine are juxtaposed). Formycin A has a wide variety of biological effects, including some in vivo anticancer activity."'In terms of metabolism in mammalian cells, it is phosphorylated by adenosine kinase, carried all the ...