Design, synthesis and biological evaluation of bivalent ligands against A1–D1 receptor heteromers

J Shen, L Zhang, W Song, T Meng, X Wang…

Index: Shen, Jian; Zhang, Lei; Song, Wan-Ling; Meng, Tao; Wang, Xin; Chen, Lin; Feng, Lin-Yin; Xu, Ye-Chun; Shen, Jing-Kang Acta Pharmacologica Sinica, 2013 , vol. 34, # 3 p. 441 - 452

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Citation Number: 5

Abstract

Aim: To design and synthesize bivalent ligands for adenosine A 1–dopamine D 1 receptor heteromers (A 1–D 1 R), and evaluate their pharmacological activities. Methods: Bivalent ligands and their corresponding A 1 R monovalent ligands were designed and synthesized. The affinities of the bivalent ligands for A 1 R and D 1 R in rat brain membrane preparation were examined using radiolabeled binding assays. To demonstrate the formation of A 1– ...