Synthesis and biological evaluation of 7-hydroxy-3, 4-diphenyl-1, 2-dihydroisoquinolines as new 4-hydroxytamoxifen analogues.

…, M NUKATSUKA, H MATSUMOTO, T TOKO

Index: Kihara, Masaru; Ikeuchi, Motoki; Yamauchi, Aiko; Nukatsuka, Mamoru; Matsumoto, Hiroshi; Toko, Toshiyuki Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 939 - 943

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Citation Number: 9

Abstract

A phenolic 3, 4-diphenyl-1, 2-dihydroisoquinoline derivative (4a) as a new 4- hydroxytamoxifen analogue and a related compound (4c) were synthesized from 3, 4- diphenyl-1, 2, 3, 4-tetrahydroisoquinolin-ols (5a, c), which were prepared by intramolecular Barbier reaction of N-(2-iodobenzyl) phenacylamines. Anti-proliferative activities of 4a, c and 5a, c, as well as 4b and 5b prepared previously, against human mammary carcinoma ...