Tetrahedron

Incorporation of carbohydrates and peptides into large triazine-based screening libraries using automated parallel synthesis

GR Gustafson, CM Baldino, MME O'Donnell, A Sheldon…

Index: Gustafson, Gary R.; Baldino, Carmen M.; O'Donnell, Mary-Margaret E.; Sheldon, Adrian; Tarsa, Robert J.; Verni, Christopher J.; Coffen, David L. Tetrahedron, 1998 , vol. 54, # 16 p. 4051 - 4065

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Citation Number: 74

Abstract

A procedure for the sequential, selective derivatization of cyanuric chloride that allows for the incorporation of carbohydrates and peptides has been elucidated. As a result, large combinatorial arrays of individual derivatives, over 40,000 in all, have been produced in 50μmole quantities using automated parallel solution phase synthesis. The use of this technology in a search for protease inhibitors, glycopeptide surrogates and other bioactive ...