Enzymic synthesis and biochemical activity of various indazole adenine dinucleotides

S Tono-oka, Y Tone, V E. Marquez…

Index: Witt; Noelting; Grandmougin Chemische Berichte, 1892 , vol. 25, p. 3156 Full Text Show Details Tono-Oka; Tone; Marquez; et al. Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 1 p. 309 - 315

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Citation Number: 13

Abstract

Each of 5-or 6-amino-, acetamido-, hydroxy-, methoxy-, and chloroindazoles (including an unsubstituted one) and β NAD were subjected to an NADase-catalyzed base-exchange reaction to produce a corresponding title compound with a 41–76% yield. A difficulty, due to the poor solubility in water of indazole bases, was overcome by the addition of DMSO (∼ 20%) without a remarkable decrease in NADase activity. In most cases, the obtained ...