Synthesis and antibacterial activity of some 1-(2-propynyl) and 1-propadienyl derivatives of 1, 4-dihydro-4-oxoquinoline-3-carboxylic acids and similar heterocycles

S Rádl, L Kovářová, J Holoubek

Index: Radl, Stanislav; Kovarova, Lenka; Holubek, Jiri Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 2 p. 439 - 448

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Citation Number: 10

Abstract

Abstract N-Alkylation of IIIa, IIIb, IIId-IIIf and 9-acridanone with 3-bromopropyne in dimethyl sulfoxide in the presence of potassium carbonate yielded N-(2-propynyl) derivatives IVa-IVe and VIa, respectively. Ethyl esters IVa, IVb, and IVe were hydrolyzed to IVf-IVh, respectively. Compounds IVf, IVg, IVctreated with bases yielded N-propadienyl derivatives Va-Vc. On the other hand 2-substituted compounds IVd and IVh did not change under the same ...