Inactivation of medium-chain acyl-CoA dehydrogenase by a metabolite of hypoglycin: characterization of the major turnover product and evidence suggesting an …

MT Lai, D Li, E Oh, HW Liu

Index: Lai, Ming-tain; Li, Ding; Oh, Eugene; Liu, Hung-wen Journal of the American Chemical Society, 1993 , vol. 115, # 5 p. 1619 - 1628

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Citation Number: 71

Abstract

Abstract: Medium-chain acyl-CoA dehydrogenase (MCAD) is a FAD-dependent enzyme that catalyzes the first step of the fatty acid oxidation cycle. When MCAD is exposed to ( methylenecyclopropy1) acetyl-CoA (MCPA-CoA), a metabolite of hypoglycin A and the causative agent of Jamaican vomiting sickness, time-dependent inactivation follows with concomitant bleaching of the active-site FAD. Earlier studies have led to the postulation ...