Nitrogen-appended N-alkylsulfonamides as inhibitors of γ-secretase

CP Bergstrom, CP Sloan, HH Wang, MF Parker…

Index: Bergstrom, Carl P.; Sloan, Charles P.; Wang, Henry H.; Parker, Michael F.; Smith, David W.; Zheng, Ming; Hansel, Steven B.; Polson, Craig T.; Barber, Lauren E.; Bursuker, Isia; Guss, Valerie L.; Corsa, Jason A.; Barten, Donna M.; Felsenstein, Kevin M.; Roberts, Susan B. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 175 - 178

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Citation Number: 9

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis and γ-secretase inhibition data for a series of nitrogen-appended N-alkylsulfonamides (11–47) are described. Inhibition of brain Aβ in transgenic mice was demonstrated by two of these compounds (23 and 44). ... Structure–activity relationships of nitrogen-appended N- ...