Regioselective synthesis of substituted pyrroles: efficient palladium-catalyzed cyclization of internal alkynes and 2-amino-3-iodoacrylate derivatives

…, JF Mehlmann, L Nogle, R Dooley, PE Mahaney

Index: Crawley, Matthew L.; Goljer, Igor; Jenkins, Douglas J.; Mehlmann, John F.; Nogle, Lisa; Dooley, Rebecca; Mahaney, Paige E. Organic Letters, 2006 , vol. 8, # 25 p. 5837 - 5840

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Citation Number: 50

Abstract

The first efficient and regioselective palladium-catalyzed cyclization of internal alkynes and 2- amino-3-iodoacrylates to give moderate to excellent yields of highly functionalized pyrroles has been developed. This approach is applicable to a range of alkynes and affords the deacylated pyrrole under reaction conditions for most substrates.