Tetrahedron

A mild cyclodesulfurization of N-(2-hydroxyethyl)-N′-phenylthioureas to 2-phenylamino-2-oxazolines using TsCl/NaOH

TH Kim, N Lee, GJ Lee, JN Kim

Index: Kim, Taek Hyeon; Lee, Namgun; Lee, Gue-Jae; Kim, Jae Nyoung Tetrahedron, 2001 , vol. 57, # 33 p. 7137 - 7141

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Citation Number: 29

Abstract

2-Amino-2-oxazolines are of particular interest as biological active molecules such as a potent adrenoceptor agonist, 1 imidazoline receptor agonist, 2 and octopaminergic agonist. 3 This interest has stimulated considerable research in the preparation of a variety of compounds.