Mild conditions are described that allow the palladium-catalyzed cross-coupling of C α -alkynylated glycine with a wide variety of electron-rich and electron-poor aryl and heteroaryl halides in aqueous media. ... Figure 1 General strategy for synthesis of novel amino acids. ... Application of the previously reported cross-coupling procedure to the preparation of C α -(ω-aryl)alkynylated glycine was initially frustrated by the failure of attempts to obtain the required C α -propargylated and - ...
