Philip Kocienski" and Clive Yeates Department of Organic Chemistry, The University, Leeds LS2 9JT, U. K. ... The nucleophilic cleavage of the oxirane (4) by the organocuprate derived from 6-lithio-3-ethyl-3,4-dihydro-2H-pyran (3) was the key step in a synthesis of racemic talaromycin B (7). ... The fungus Tala romy ces s tip itat us infects w ood-s havings- based chicken litter. Two isomeric toxic metabolites have been isolated from cultures of T. stipitatus which appear ...
