Synthesis and anti-Trypanosoma cruzi activity of β-lapachone analogues

SB Ferreira, K Salomão, FC da Silva, AV Pinto…

Index: Ferreira, Sabrina Baptista; Salomao, Kelly; De Carvalho Da Silva, Fernando; Pinto, Antonio Ventura; Kaiser, Carlos Roland; Pinto, Angelo C.; Ferreira, Vitor Francisco; De Castro, Solange L. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3071 - 3077

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Citation Number: 38

Abstract

The available chemotherapy for Chagas disease, caused by Trypanosoma cruzi, is unsatisfactory; therefore, there is an intense effort to find new drugs for the treatment of this disease. In our laboratory, we have analyzed the effect on bloodstream trypomastigotes of 16 new naphthoquinone analogues of β-lapachone modified in the pyran ring, aiming to find a new prototype with high trypanocidal activity. The new compounds presented a broad ...