Synthesis of [6.6] Metacyclophane via the Suzuki Coupling

…, WR Kwochka, R Damrauer, RJ Swope…

Index: Smith, Beverly B.; Kwochka, William R.; Damrauer, Robert; Jeffrey Swope; Smyth, Joseph R. Journal of Organic Chemistry, 1997 , vol. 62, # 24 p. 8589 - 8590

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Citation Number: 8

Abstract

Cyclophane chemistry has contributed greatly to the understanding of fields as varied as molecular and cationic recognition to fundamental principles of NMR. 2 To date, the largest all-carbon [n. n] metacyclophane prepared is [5.5] metacyclophane, which was synthesized by the acid-catalyzed dimerization of δ-2-methoxyphenylvaleric acid, yet no conformational information is available about this system. 3[4.4] Metacyclophane has been prepared by a ...