Enantioselective and Regioselective Friedel–Crafts Alkylation of Pyrroles with Nitroalkenes Catalyzed by a Tridentate Schiff Base–Copper Complex

…, G Lai, T Zhu, S Xiong, S Wang, Z Wang

Index: Guo, Fengfeng; Chang, Dalu; Lai, Guoyin; Zhu, Tao; Xiong, Shunshun; Wang, Sujing; Wang, Zhiyong Chemistry - A European Journal, 2011 , vol. 17, # 40 p. 11127 - 11130

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Citation Number: 27

Abstract

Over the past decade, the catalytic asymmetric Friedel–Crafts alkylation reaction of aromatic compounds with electron-deficient alkenes has attracted considerable interest because of its ability to construct useful chiral aryl-substituted compounds.[1] Among these remarkable advances, examples of the use of pyrroles as substrates remain relatively unexplored,[2, 3] partially due to their instability towards the usual Lewis acids.[4] The asymmetric Friedel– ...