Insights into structure–activity relationships from lipophilicity profiles of pyridin-2 (1H)-one analogs of the cardiotonic agent milrinone

M de Candia, P Fossa, S Cellamare, L Mosti…

Index: Fossa; Boggia; Lo Presti; Mosti; Dorigo; Floreani Farmaco, 1997 , vol. 52, # 8-9 p. 523 - 530

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Citation Number: 21

Abstract

The pH-dependent distribution profiles of a series of pyridin-2 (1H)-one analogs of the inotropic/vasodilator agent milrinone, determined in 1-octanol/water (and for a number of them also in chloroform–water) using a pH-metric technique, showed that partition