Anthraquinones as Artificial DNA Building Blocks

N Bouquin, VL Malinovskii…

Index: Bouquin, Nicolas; Malinovskii, Vladimir L.; Haener, Robert European Journal of Organic Chemistry, 2008 , # 13 p. 2213 - 2219

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Citation Number: 3

Abstract

Abstract Synthesis and properties of oligodeoxynucleotides containing anthraquinone- derived building blocks with flexible linkers are described. Starting from the 1, 4-, 1, 5-, 1, 8- and 2, 6-dihydroxyanthraquinone isomers, the corresponding phosphoramidites were prepared and incorporated into oligonucleotides. The site of linker attachment was found to be of critical importance for hybrid stability. Whereas the 2, 6-isomer led to a significant ...