A new method for the synthesis of fluoromethylenecyclopropane nucleosides by alkylation– elimination procedure is described. Fluorination of methylenecyclopropane carboxylate gave fluoroester. Treatment of with phenylselenenyl bromide afforded the desired ethyl (E)-2- bromomethyl-1-fluoro-2-phenylselenenylcyclopropane-1-carboxylate in 85% yield. DIBALH reduction of gave, which after acetylation to was reacted with 2-amino-6-chloropurine to ...
